Osteoarthritis (OA) is one of the most common debilitating diseases experienced within an ageing population and constitutes an urgent medical need. Obesity, a major risk factor, is further increasing prevalence and occurrence of OA. Approximately 30% of the global population over 60 years of age, suffers from OA and have no disease modifying treatment options. OA largely affects weight bearing joints such as the knee joint & hip joint amongst others. Existing treatment options available include NSAIDs, glucosamine & chondroitin sulphate, Hyaluronic Acid injections (HA), Diacerin (IL-1 inhibitor ), or steroid injections. All of these treatments focus on providing temporary pain relief and reducing inflammation during early stages of disease without affecting the course of the disease. All patients ultimately, if able to undergo surgery, will require total knee replacement.